An introduction to ex vivo lung perfusion (EVLP): innovation designed to increase the pool of available donor lungs for transplantation.
IMPORTANT SAFETY INFORMATION FOR XVIVO PERFUSION SYSTEM (XPS™) WITH STEEN SOLUTION™ PERFUSATE - P180014
Warnings and Precautions
General Warnings
The safety and effectiveness of the XPS™ System with STEEN Solution™ Perfusate device were not evaluated with ideal criteria donor lungs.
Risk for Contamination and Mechanical Trauma
The degree of organ manipulation required for airway and vascular cannulation carries the potential for contamination and mechanical trauma of the donor lungs. Even though not contraindicated, it is not recommended to use an organ with evident signs of mechanical trauma or major contamination.
Please see full Important Safety Information by clicking the button below
Viable solutions for challenging organs
For many patients suffering with end-stage lung disease, transplant is their only lifeline.
Yet, the number of patients on the lung transplant wait list significantly exceeds the amount of available donor lungs.
What makes a placing donor lung challenging? EVLP aims to find new answers to this question and uncover more possibilities for more patients.
Organ Shortage Continues in the U.S
Annual Number of Patients on Waiting List, Transplants Received, and Living and Deceased Donors in the United States, 1991–2019
What is EVLP?
EVLP is a technique used to evaluate donor lungs outside of the human body.
It has emerged as an essential tool for transplant physicians to increase the number of lungs available for transplantation.
For example, when marginal lungs do not meet standard direct-to-transplant criteria, they are often not used. With the help of EVLP,
marginal lungs can now be monitored and clinically assessed to help transplant centers determine transplant suitability.
EVLP is innovation that gives lungs a second chance.
The EVLP difference
further evaluation
Facilitates the use of donor lungs by providing further evaluation of organs.
OPPORTUNITY TO INCREASE conversion rate
Aims to increase the conversion rate of donor lungs that would otherwise have gone unused.
added time
Can provide additional time in circumstances where procurement occurs without comprehensive evaluation.
FLEXIBILITY in recipient transplant timing
Provides flexibility in recipient transplant timing when there is a need for prospective crossmatch and further recipient testing, donor instability, DCDs (Donation after Circulatory Death) or explant of native lungs.
Increased confidence
Increases confidence in using lungs recovered by other teams, decreasing dry runs by transplant center explant teams so that they can successfully transplant more lungs.
backup modality
Makes the assessment of additional lungs possible via access to EVLP as a backup modality.
Interested in learning more? Browse our EVLP library below.
1
EX VIVO PERFUSION TECHNIQUES: STATE OF THE ART AND POTENTIAL APPLICATIONS
Marcelo Cypel, Arne Neyrinck and Tiago N. Machuca
2
EX VIVO LUNG PERFUSION: CURRENT ACHIEVEMENTS AND FUTURE DIRECTIONS
Nikhil K. Prasad, MB, ChB, Chetan Pasrija, MD, Tara Talaie, MD, Alexander S. Krupnick, MD, Yunge Zhao, MD, PhD, and Christine L. Lau, MD, MBA
3
A POTENTIAL SOLUTION TO THE SHORTAGE OF SOLID ORGANS FOR TRANSPLANTATION
Stephen P. Wall, MD, MSc, MAEd; Carolyn Plunkett, MA; Arthur Caplan, PhD
4
EXTENDED POST-EX VIVO LUNG PERFUSION COLD PRESERVATION PREDICTS PRIMARY GRAFT DYSFUNCTION AND MORTALITY: RESULTS FROM A MULTICENTRIC STUDY
Leiva-Juárez, Miguel M. et al.
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